Protein Shapes Matter in Alzheimer’s Research

Often proteins misfold. When that transpires in the human mind, the pileup of misfolded
proteins can guide to neurodegenerative ailments like Alzheimer’s, Parkinson’s and

Proteins do not misbehave and misfold out of the blue. There is a fragile ecosystem
of biochemical interactions and environments that normally allow them twist, unfold,
refold and do their jobs as they’re intended to. 

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Having said that, as scientists from Michigan Technological College take a look at in an article
released in
ACS Chemical Neuroscience, even a small alter might trigger extended-term implications. 

For amyloid beta peptides — thought of a main hallmark of Alzheimer’s condition — a 
widespread chemical modification at a certain spot on the molecule has a butterfly
impact that prospects to protein misfolding, aggregation and mobile toxicity. 

Acetylation and Amyloid Beta Toxicity

Ashutosh Tiwari, affiliate professor of chemistry at Michigan Tech, describes that misfolded amyloid beta

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